COLEUS EXTRACT
FORSKOHLII 10% and 20%
Botanical Name : Coleus Forskohlii
Parts Used : Rhizome
Species : P. barbatus
INTRODUCTION
Coleus Forskohlii Herb Extract is drived from roots from Coleus Forskohlii. Coleus is used in India folk medicines and is a traditional digestive remedy. Currently the plant is extensively cultivated is Southern India. Forskohlii helps to lower blood pressure, dilates the blood vessels. It is concerted to be a good Heart tonic.
Plectranthus barbatus, or more commonly known as Coleus forskohlii and Indian Coleus (Kikuyu: Maigoya), is a tropical perennial plant related to the typical coleus species. It is interesting from a scientific and medicinal standpoint because it produces forskolin
This "power" herb has an active ingredient in it called forskolin. It has been used in ayruvedic medicine for many years. Forskolin's basic mechanism of action is that it increases the amount of cyclic AMP (adenosine monophosphate) in cells by activating an enzyme called adenylate cyclase. Cyclic AMP (cAMP) is one of the most important secondary messengers in the cell. It is considered to be one of the most important cell regulating compounds. Under normal circumstances, cAMP forms by adenylate cyclase activation due to hormonal stimulation at the cell receptor site. However, forskolin seems to bypass this reaction and allows for an increase in intracellular cAMP to occur. Why is it important to increase cAMP levels? Well, there are several benefits of this to athletes including relaxation of the arteries and smooth muscles, lowering blood pressure, enhanced insulin secretion (which can help drive carbohydrates and protein into muscle cells for energy and recovery), increased thyroid hormone function (which can help enhance metabolic rate), and significantly increase lipolysis (fat burning). Forskolin also seems to benefit other cellular enzymes as well.
The breakdown of fat for fuel (lipolysis) is actually regulated by cAMP. Forskolin has been shown to not only enhance lipolysis but it may also inhibit fat storage from occurring. This is very good news for individuals trying to lose bodyfat and get lean. Another way that forskolin may allow for fat loss to occur is by stimulating thyroid hormone production and release. Thyroid hormone controls metabolism and can enhance metabolic rate, which may translate into more fat loss.
One of the overlooked benefits of forskolin includes its stimulation of digestive enzymes, which can allow individuals to digest and assimilate their food better. It has been shown to increase nutrient absorption in the small intestine.
Forskolin has been shown to be safe and effective and has a great amount of potential as a sports supplement. As with most dietary supplements, more human research is needed but the future looks bright for this compound. The roots are extracted with different solvents, the extract is purified and isolated in various concentration.
Therapeutic Applications
Specifications
Description
Dark reddish brown to brown powder
Identification
By TLC
PH of 1% w/v solution
4-6
Bulk density (g/cc)
0.20 – 0.80
LOD
NMT 6% w/w
Material passing through 60#
>95%
Heavy Metal
Lead
NMT 10 ppm
Arsenic
NMT 2 ppm
Cadmium
NMT 1 ppm
Microbiological Analysis
Total viable aerobic count
NMT 10000 cfu/mg
Total fungal count
NMT 100 cfu/mg
Total enterobacteriaceae
Escherichia Coli
Absent
Salmonella Species
Staphylococcus Aurous
Pseudomonas Aeruginosa
Assay Content of Forksholin by HPLC
NLT 10% AND 20% AND NMT12% AND 22% RESP.
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